Molecular Investigation of SARS-CoV-2 Proteins and Their Interactions with Antiviral Drugs.
Identifieur interne : 000474 ( 2020/Analysis ); précédent : 000473; suivant : 000475Molecular Investigation of SARS-CoV-2 Proteins and Their Interactions with Antiviral Drugs.
Auteurs : Paolo Calligari [Italie] ; Sara Bobone [Italie] ; Giorgio Ricci [Italie] ; Alessio Bocedi [Italie]Source :
- Viruses [ 1999-4915 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Protéines virales.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Humains, Pandémies, Simulation de docking moléculaire.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Viral Proteins.
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Drug Development, Humans, Molecular Docking Simulation, Pandemics.
Abstract
A new Coronavirus strain, named SARS-CoV-2, suddenly emerged in early December 2019. SARS-CoV-2 resulted in being dramatically infectious, with thousands of people infected. In this scenario, and without effective vaccines available, the importance of an immediate tool to support patients and against viral diffusion becomes evident. In this study, we exploit the molecular docking approach to analyze the affinity between different viral proteins and several inhibitors, originally developed for other viral infections. Our data show that, in some cases, a relevant binding can be detected. These findings support the hypothesis to develop new antiviral agents against COVID-19, on the basis of already established therapies.
DOI: 10.3390/v12040445
PubMed: 32295237
Affiliations:
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pubmed:32295237Le document en format XML
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SARS-CoV-2 resulted in being dramatically infectious, with thousands of people infected. In this scenario, and without effective vaccines available, the importance of an immediate tool to support patients and against viral diffusion becomes evident. In this study, we exploit the molecular docking approach to analyze the affinity between different viral proteins and several inhibitors, originally developed for other viral infections. Our data show that, in some cases, a relevant binding can be detected. These findings support the hypothesis to develop new antiviral agents against COVID-19, on the basis of already established therapies.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Calligari, Paolo" sort="Calligari, Paolo" uniqKey="Calligari P" first="Paolo" last="Calligari">Paolo Calligari</name></region><name sortKey="Bobone, Sara" sort="Bobone, Sara" uniqKey="Bobone S" first="Sara" last="Bobone">Sara Bobone</name><name sortKey="Bocedi, Alessio" sort="Bocedi, Alessio" uniqKey="Bocedi A" first="Alessio" last="Bocedi">Alessio Bocedi</name><name sortKey="Ricci, Giorgio" sort="Ricci, Giorgio" uniqKey="Ricci G" first="Giorgio" last="Ricci">Giorgio Ricci</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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